Bacterial metabolites directly modulate farnesoid X receptor activity
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چکیده
منابع مشابه
Bacterial metabolites directly modulate farnesoid X receptor activity
BACKGROUND The farnesoid X receptor (FXR), a ligand-activated transcription factor belonging to the adopted orphan receptor, plays an important role in maintaining health of the liver and intestine. In this study, we identified individual bacterial strains that directly modulated the activation of intestinal FXR. METHODS The FXR stimulatory potential of 38 bacterial strains was determined usi...
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The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that functions as an endogenous sensor for bile acids and regulates cholesterol and fatty acid metabolism. The effect of FXR activation on aortic plaque formation was assessed by feeding apolipoprotein E-deficient (ApoE-/-) mice with the synthetic FXR ligand INT-747, a cheno-deoxycholic acid derivative, at doses of 3...
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OBJECTIVE The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling through the bile acid nuclear receptor farnesoid X receptor (FXR) contribute to impaired host metabolism. Here we investigated if the gut microbiota modulates obesity and associated phenotypes throu...
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ژورنال
عنوان ژورنال: Nutrition & Metabolism
سال: 2015
ISSN: 1743-7075
DOI: 10.1186/s12986-015-0045-y